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Saturday, May 16, 2020 | History

2 edition of Bioassay of n-nitrosodiphenylamine for possible carcinogenicity. found in the catalog.

Bioassay of n-nitrosodiphenylamine for possible carcinogenicity.

National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

Bioassay of n-nitrosodiphenylamine for possible carcinogenicity.

by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

  • 162 Want to read
  • 29 Currently reading

Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens.,
  • Nitrosoamines -- Toxicology.

  • Edition Notes

    SeriesCarcinogenesis technical report series ; no. 164, DHEW publication ; no. (NIH) 79-1720, National Cancer Institute carcinogenesis technical report series -- no. 164., DHEW publication -- no. (NIH) 79-1720.
    The Physical Object
    Paginationx, 106 p. :
    Number of Pages106
    ID Numbers
    Open LibraryOL17538515M

    A scheme for ranking the quantitative activity of chemical carcinogens is described. This activity scheme uses as its base, dose potency measured as TD 50, the chronic dose rate that actuarially halves the adjusted percentage of tumor-free animals at the end of the study (Gold et al., Perspect., 67, –, ).Cited by: Presented below are water quality standards that are in effect for Clean It is the goal of these water quality standards, wherever possible, that all surface N-Nitrosodiphenylamine E+OO B,C E+OO B,C 65FR 65FR

    Find N-Nitrosodiphenylamine at now. Great deals on chemicals and chemical supplies.5/5(7). The aim of the present study was to assess the carcinogenicity of daminozide alone and in combination with l,l-dimethylhydrazine (UDMH), its major contaminant, in a novel medium-term bioassay in Fischer rats, the diethylnitrosamine-hepatectomy model. Rats were given diethylnitrosamine (DEN) at mg/kg body weight intraperitoneally and.

    Full text of "Casarett and Doull's toxicology: the basic science of poisons" See other formats. Full text of "Monthly catalog of United States government publications" See other formats.


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Bioassay of n-nitrosodiphenylamine for possible carcinogenicity by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Download PDF EPUB FB2

Get this from a library. Bioassay of n-nitrosodiphenylamine for possible carcinogenicity. [National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.].

N-NITROSODIPHENYLAMINE. FOR POSSIBLE CARCINOGENICITY. Careinogenesis Testing Program. Division of Cancer Cause and Prevention National Cancer Institute National Institutes of Health Bethesda, Maryland U.

DEPARTMENT OF HEALTH, EDUCATION, AND WELFARE Public Health Service National Institutes of Health NIH Publication No. N-Nitrosodiphenylamine (NDFA) has been determined using thin layer (Ref. ), liquid (Ref. ), and gas (Ref. ) chromatographic techniques.

Methods that utilize gas chromatography are somewhat tedious because a cleanup procedure, to separate NDFA from diphenylamine (DFA), must be performed prior to GC no.: N-Nitrosodiphenylamine may be ignited by heat, sparks, or flames; burning with a flare-like effect and the possible production of irritating or poisonous gases.

Fires involving N-nitrosodiphenylamine may be extinguished with dry chemical, sand, water spray, fog, or foam. For a massive fire, use unmanned hose holders. Although EPA has classified n-nitrosodiphenylamine as a probable carcinogen, the animal data are limited.

Other public health agencies have concluded that no evaluation of n-nitrosodiphenylamine's carcinogenicity in people is currently. Summary: n-Nitrosodiphenylamine is an industrial compound. It is an orange-brown or yellow solid that has been produced since n-Nitrosodiphenylamine is used to make rubber products such as tires or to make other chemicals.

In the early s, most U.S. rubber manufacturers replaced it with more efficient chemicals. Author(s): Frederick Cancer Research Center.; National Institutes of Health (U.S.); Carcinogenesis Testing Program (U.S.) Title(s): Bioassay of n. N-Nitrosodibutylamine was the principal nitrosamine found Mean total volatile N-nitrosamine levels for baseline and compliance samples were and ppb, resp.

The pacifier lots sampled after January 1, had a significant decrease in contamination levels, indicating that at least 98% of the market share is in compliance with the. N-Nitrosodiphenylamine (NDFA) has been determined using thin layer (Ref.

), liquid (Ref. ), and gas (Ref. ) chromatographic techniques. Methods that utilize gas chromatography are somewhat tedious because a cleanup procedure, to separate NDFA from diphenylamine (DFA), must be performed prior to GC analysis.

Explore information about Air pollutants, contaminants and studies being done. ALS Environmental may or may not test for N-Nitrosodiphenylamine (CAS # ). Information is subject to change; please contact us for the latest available analytes for which we test.

ALS Environmental does not sell chemicals, but offers analytical lab testing to determine the presence of various elements and chemical compounds. N-NITROSODIPHENYLAMINE may be sensitive to moisture at elevated temperatures in strongly acidic solutions.

May react vigorously with oxidizing agents. OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for. Bioassay of N- Nitrosodiphenylamine for Possible Carcinogenicity.

NCI Carcinogenesis Tech Rep Ser No (also publ. as NIH and NTIS PB ). 56 Section 10 NIOSH (National Institute of Occupational Safety and Health). Further studies in mammals are required to determine if this potential is expressed as heritable genetic change or as carcinogenicity.

It must be stressed that meaningful evaluations are dependent on a group of assays in a screening phase because no single assay can perform the safety evaluation function by: 4. National Cancer Institute () Bioassay of N-Nitrosodiphenylamine for Possible Carcinogenicity (Tech.

Rep. Ser. ; DHEW Publ. (NIH) ), US Government Printing Office, Washington, by: 5. NIH Publ No 79– () Bioassay of N-nitrosodiphenylamine for possible carcinogenicity. Natl Cancer Inst, Bethesda, Maryland Google Scholar NIH Publ No 79– () Bioassay of p-quinone dioxime for possible by: 1.

N-Nitrosodiphenylamine is an orange-brown or yellow solid. It evaporates slowly to the air and can attach to dust particles and travel with the wind.

It can dissolve in water and attach to soil. It breaks down to other substances, but we do not know whether these substances are harmful to humans, We have not found N-nitrosodiphenylamine in. Diphenylamine + N-Nitrosodiphenylamine ALS Environmental may or may not test for Diphenylamine + N-Nitrosodiphenylamine (CAS # CASID).

Information is subject to change; please contact us for the latest available analytes for which we test. In silico methods for predicting mutagenicity and rodent carcinogenicity based on chemical structural features, along with current mutagenicity and.

Two carcinogens (5-chloro-o-toluidine, 1,1,2,2-tetrachloroethane) may have a genotoxic element to their carcinogenicity and may have been expected to.

Editor's note: Some chemicals in this database contain more information than others due to the original reason this information was collected and how the compilation was accomplished.

While working with material safety data sheets (MSDS), I found that manufacturers sometimes used obscure names for constituent chemicals and I didn't always have a good idea of what I was .DATE: SUBJECT: FROM: TO: December 2, Background Document: Resource Conservation and Recovery Act Subtitle C VotAtt-t- J/£lA-Vj.^/H X^-^ Angela'WTlkes, Publications Officer Office of Solid Waste (WH) EPA Regional and Headquarters Librarians Background Documents "Listing of Hazardous Wastes (Section Parts .First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Ingestion: Do not eat, drink, or smoke during work. Rinse mouth. Refer for medical attention.